Lazio v AC Milan: probable line-ups for Serie A fourth-round clash

Lazio and AC Milan meet on Saturday, 12 September 2026, at 16:00 GMT in the fourth round of Serie A, with both sides expected to field strong line-ups.

Lazio

Lazio manager Gattuso is expected to have almost all of his senior players available for the fixture, with few significant absences reported.

The Rome side also have several alternatives on the bench across the pitch. Defensive experience, pace out wide and players capable of influencing the match late on give Lazio useful options during the game.

That depth could become important if the contest remains intense into the second half. With a well-stocked squad and the ability to adjust their approach, Lazio are likely to approach the match with ambition.

Lazio’s probable starting XI is:

Goalkeeper: C. Mandas

Defenders: Romano Floriani, D. Doekhi, O. Provstgaard, Nuno Tavares

Midfielders: Davide Frattesi, R. Belahyane, K. Taylor

Forwards: Gustav Isaksen, A. Pinamonti, M. Zaccagni

AC Milan

AC Milan are expected to use a 3-6-1 formation under Ruben Amorim for the trip to Lazio.

The system is designed to provide additional protection through a back three while giving the team numerical strength in midfield. The wide players will be expected to provide width and cover significant ground, while those in central areas take responsibility for winning the ball and starting attacks.

With one forward leading the line, AC Milan will look to use crosses and service from the flanks to create opportunities. The formation should offer greater control in midfield, although it will require considerable energy and discipline to prevent Lazio from exploiting space on the wings.

AC Milan’s probable starting XI is:

Goalkeeper: M. Maignan

Defenders: S. Pavlovic, Koni De Winter, D. Bartesaghi

Midfielders: P. Estupinan, A. Saelemaekers, Yunus Musah, Luka Modric, Adrien Rabiot, Diego Moreira

Forward: Goncalo Ramos

The match will be Lazio’s fourth-round Serie A fixture against AC Milan. The listed prices make Lazio 3.30 to win, with a draw at 3.20 and an AC Milan victory at 2.20.