Espérance Sportive de Tunis will take on Étoile du Sahel in a crucial Tunisian Ligue 1 clash on Wednesday at Hammadi Agrebi Stadium in Rades.
The match will determine sole leadership of the league, with both teams currently tied on 45 points.
Espérance, however, hold the advantage on goal difference and also claimed a 2-0 victory in the reverse fixture at the Olympic Stadium in Sousse.
After a slow start to the season, Espérance managed to climb to the top of the table through a consistent run of victories.
However, their momentum was disrupted in the last round following a defeat against CA Bizertin over the weekend.
With the club also preparing for a CAF Champions League quarterfinal clash against South African giants Mamelodi Sundowns, Espérance will be eager to return to winning ways.
They will be without key players Kossi Semedo and Khalil Chniba due to suspension, while Brazilian forward Rodrigo Rodrigues remains sidelined with an injury.
Étoile du Sahel, led by coach Mohamed Mkacher, has made an impressive turnaround this season, rising from the lower half of the table to emerge as strong title contenders.
The team is aiming for its first victory over Espérance since 2015 and is determined to claim its 12th league title.
Elsewhere in the league, CA Bizertin will face ES Zarzis, while US Métlaoui is set to clash with Stade Gabésien.
In another key fixture, AS Soliman and JS Omrane will battle in a matchup crucial for avoiding relegation.
