The 2025/26 CAF Confederation Cup quarterfinals will kick off with the first legs on 15 March 2026, before the decisive return fixtures a week later on 22 March 2026.
These home-and-away ties will determine which four clubs advance to the semi-finals as the competition enters its most intense phase.
Eight ambitious teams from across the continent are involved, each just two rounds away from the final.
The draw has produced some heavyweight clashes and intriguing storylines, with champions from North and Central Africa facing off against emerging forces eager to make history. Travel, away goals, and squad depth will all play a key role over the two weekends of action.
The confirmed pairings for the quarterfinals are:
Al Masry (Egypt) vs CR Belouizdad (Algeria)
Olympique Safi (Morocco) vs Wydad Athletic Club (Morocco)
AS Otoho (Congo) vs Zamalek (Egypt)
Maniema Union (DR Congo) vs USM Alger (Algeria)
With tight schedules across domestic leagues and continental commitments, coaches will need to rotate wisely while still fielding strong lineups to handle the high stakes of knockout football.
